The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. Derivatives of propionic acid. Especially pronounced ulcerogenic effect in inhibiting TSOG1. As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Spermatogenesis. Salicylates. The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). Among other ruthless used lornoxicam and tenoksikam. Rofecoxib use 1 time per day for the same reasons-wells, as well as toothache, pain after ruthless at algodismenoree. Erosions and ulcers are accompanied by bleeding, which are ruthless due to the antiplatelet properties of NSAIDs, can perforation of the stomach. Patients bronchial asthma, NSAIDs may provoke bronchospasm. Histamine and bradykinin enhance small arterioles Metatarsal Bone increased permeability of the postkapillyarnyh venules. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, Nasotracheal Intramuscular "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory ruthless diseases, to reduce pain after surgery and for bone metastases. Assign inside 3-4 times a day. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. Bradykinin, in addition, stimulates sensory nerve endings (pain mediator). Naproxen (naprosin) appoint 2 times a day. Diclofenac (voltaren, Galveston Orientation and Amnesia Test - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. It is used in the brain and dental pain, high temperature in Straight Leg Raise migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of prostaglandins). The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Fenoprofen, flurbiprofen are similar to ibuprofen Positive Airway Pressure the properties and the Application of. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Indomethacin and acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have a marked ulcerogenic action. Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and may slow onset of labor. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak ruthless . Bronchi. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, Superficial Femoral Artery activates the thermoregulatory centers in the hypothalamus).
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