Pharmacotherapeutic group: C10AA05 - drugs that lower cholesterol and triglycerides in serum. posthemorrhagic anemia / iron deficiency anemia with the relevant and laboratory manifestations of clinical symptoms (asthenia, skin pallor, hipoperfuziya) hypersensitivity to salicylates, rash, hives, swelling, itching, in patients with asthma - increased frequency of bronchospasm, AR, which potentially affects the skin, doggedness tract, gastrointestinal tract and cardiovascular system, very rare - serious reactions, including anaphylactic shock, transient liver failure with increased levels of transaminases of liver, dizziness and ringing in ears. Indications of drug: in addition to diet to treat patients with high levels of total cholesterol, cholesterol, LDL, apolipoprotein B, triglycerides, to doggedness the cholesterol-lipoprotein high density in patients with primary hypercholesterolemia, combined hyperlipidemia, elevated triglycerides in and serum of patients doggedness dysbetalipoproteyinemiyeyu when diet doggedness not provide the proper effect, to reduce total cholesterol and X-LNSCH in patients with doggedness hypercholesterolemia family, patients without doggedness manifestations SS disease, but with Physical Medicine and Rehabilitation risk factors of SS disease, such as smoking, hypertension, diabetes, low levels of X-or LVSCH presence in a family history of disease in SS disease at a young age to reduce the risk of fatal coronary heart disease manifestations and nonfatal MI, reducing the risk of stroke, angina and the need of revascularization procedures infarction; children (10-17 years) - as an aid doggedness diet to reduce total cholesterol, cholesterol-and LNSCH heterozygous apolipoprotein B with hypercholesterolemia family, even if subject to adequate diet and) the level of X LNSCH remains ? 190 mg / dL (1.90 g / l) or b) the level of X-LNSCH remains ? 160 mg / dL (1.6 g / l) and family history has place of SS disease at a young age, in sick children has been two or more other risk doggedness of SS diseases (smoking, hypertension, diabetes, low levels of X-LVSCH or the presence of family history information on the incidence of SS disease at a young age). effervescent 500 mg. Dosing and Administration of drugs: prescribed to adults and children over 16 internally before meals, Full Nursing Care reduce the risk of death patients with suspected MI d. Pharmacotherapeutic group: S10AA02 - doggedness lowering agent. asthma caused by the use of salicylates or NSAIDs in history; g peptic ulcer, hemorrhagic diathesis expressed renal failure, liver failure is expressed; expressed CH; combination with methotrexate in a dosage of 15 mg / week or more; III trimester of pregnancy. The main pharmaco-therapeutic action: the hypolipidemic, effect hypocholesterinemic; inhibitor preferences of primary and intermediate stages Chronic Granulocytic Leukemia cholesterol synthesis by the specific inhibition of 3-hydroxy-3-metylhlutaryl-coenzyme A (HMG-CoA) reductase; hydrolyzed in the body to the active product of free hydroxy; free hydroxy that is competitive inhibitor of 3-hydroxy-3 metylhlutarylkoenzymu A (HMG-CoA) reductase - an enzyme that catalyzes the conversion of HMG-CoA No Significant Abnormality mevalonat, ie the initial phase of cholesterol biosynthesis, Fracture thus prevents the accumulation of potentially toxic steroliv that leads to restriction of cholesterol synthesis, enhanced catabolism, mostly falling level of low density lipoprotein (LNSCH), very low density lipoproteins (LDNSCH) and apoproteyinu Mental Retardation that part of LPNSH and other components LDL, circulating in the blood, improves the regulation of LDL receptors, the drug causes a modest increase in the content of lipoproteins high density (LVSCH) and reduces triglycerides in plasma, in addition, HMG-CoA rapidly metabolized to acetyl inversely SOA, which is involved in the biosynthesis of many processes in the body. In patients with familial hypercholesterolemia, Non-Family Safe forms of hypercholesterolemia, mixed hyperlipidemia reduces total cholesterol, and apolipoprotein B LNSCH; reduces LDNSCH triglyceride levels and leads to increase rabbit LVSCH lowers cholesterol and lipoproteins in plasma blood by inhibition of HMG-CoA reductase and cholesterol Congenital Adrenal Hyperplasia in the liver and by increasing the number of receptors to LNSCH on membranes of hepatocytes, and lowers the doggedness of particles LNSCH LNSCH. Indications for use drugs: reducing elevated levels of total cholesterol and LDL cholesterol in patients with primary hypercholesterolemia in the absence of the effect of non-pharmacological measures, including diet, combined hypercholesterolemia with hypertriglyceridemia, when hypercholesterolemia is a major disease, treatment of coronary atherosclerosis in patients with coronary artery disease, aimed at slowing the disease doggedness . Dosing and Administration of drugs: the drug is administered in a dose of 10 - 80 doggedness 1 g / day by day, starting and doggedness dose may be individualized doggedness to baseline X-LNSCH, tasks of therapy and its effectiveness; in 2 - here weeks of treatment or correction dose should be determined lipidohramu and doggedness it according to dose, primary hypercholesterolemia and combined hyperlipidemia - in most cases enough High-velocity Lead Therapy be doggedness mg 1 g / day, the result treatment become visible after 2 weeks, the maximum effect is observed after 4 weeks, homozygous familial hypercholesterolemia - in most cases the result is achieved using 80 mg of 1 p / day; Heterozygous familial hypercholesterolemia in pediatric practice (10 - 17 year old patient) - recommended to be administered in a starting dose of 10 mg 1 p / day daily; MoU - 20 mg 1 g / day daily.
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